There are 17 villages in the territory of the region, the largest of them is Saru with 243 inhabitants, followed by Mõniste with 194 inhabitants and Kuutsi with 88 inhabitants.
List of some villages in the region: Hürova, Hüti, Kallaste, Karisöödi, Koemetsa, Kuutsi, Mõniste, Parmupalu, Peebu, Sakurgi, Saru, Singa, Tiitsa, Tundu, Tursa, Vastse-Roosa and Villike.
The administrative centre of the parish is located in Rõuge (27 km from Mõniste). From Mõniste it is 39 km to Võru, 46 km to Valga, 101 km to Tartu, 283 km to Tallinn, and 11 km to Ape (in the Republic of Latvia). The most important highway is the Valga-Võru highway passing through the area.
In terms of the natural environment, the Mõniste region is very varied. The landscape is diversified by a relatively large number of watercourses, forest massifs, marshes, swamps, cultivated agricultural lands, and natural grasslands.